Pre-clinical and Clinical Imaging

Imanova has particular expertise in the application of pre-clinical and clinical imaging methodologies to support the drug development process. We have pioneered novel PET/CT and MRI techniques to add value to this activity.

Our scientists have pioneered novel techniques to add value to this activity.

Our scientists and clinical staff facilitate the translation of study proposals into optimised imaging protocols and then co-ordinate their implementation.

PET/CT

→ Preclinical PET/CT Imaging (click to expand)

  • Fully equipped preclinical imaging facility
  • State of the art Siemens Inveon preclinical PET-CT scanner and blood/tissue counting lab for accurate quantification
  • High resolution (<1.4mm) and high sensitivity PET (7%)
  • High resolution CT (27 microns)

→ Clinical PET/CT Imaging (click to expand)

  • Fully compliant and audited volunteer imaging environment (GCP, IRMER,MEIGan)
  • Two Siemens clinical whole-body PET-CT scanners (Biograph 6 HiRez and TruePoint with TrueV)
    • High sensitivity PET (8kcps/MBq NEMA NU2-2007) with 21cm Field of View
    • High resolution (2mm centre FOV) PET reconstruction using Siemens TrueX PSF modeling reconstruction
    • Diagnostic quality CT capability
    • PET Respiratory and cardiac gating capability
    • Full Siemens research support/capabilities
  • Online blood sampling counting and metabolite analysis
  • Experience in running and participating in multi-centre trials

MRI

→ Clinical MRI Imaging (click to expand)

  • Two state of the art Siemens clinical whole-body 3T scanners
    • A full complement of parallel reception receiver coils, such as the 32 channel phased array head coil
    • Advanced functional stimulus and recording, infusion/bolus pumps, oxygen and clinical monitoring in both suites
    • Full Siemens research support/capabilities
  • Experience in both running and participating in multi-centre trials
  • Aside from optimised protocols for common structural scanning sequences such as T1w, T2w, FLAIR, DWI etc., many sequences and protocols have been programmed and developed in-house for quantitative imaging
    • Direct Whole-Body Fat-Specific Structural Imaging, Hepatic and Muscle Lipid Quantification with MRS and/or custom IDEAL decomposition with T1 and T2 correction
    • Advanced Diffusion Imaging with Tractography, arbitrary unlimited diffusion directions, multiple b-values, and susceptibility distortion correction, mean-axonal radius mapping
    • Functional MRI
      • BOLD EPI with Multi-echo, Z-shimming, RGPM DCE MRI in body, prostate, head and neck for oncology and brain for BBB permeability with T1 mapping and flip angle correction via B1 mapping.
      • Fully Quantified Arterial Spin Labelling (pASL) and functional ASL
      • Gd and USPIO contrast agent imaging (T1, T2, T2* mapping)
    • Sodium-23 and UTE nonCartesian imaging (joints and lungs)
      • MR Spectroscopy: Localised proton as well as 31P (muscle energetics), 19F (compound tracking), 13C (metabolics), 23Na
    • Small FOV Blood-suppressed Carotid Vessel Imaging
    • Lung Density Imaging
    • Structural Multi-contrast MPRAGE with B1 and T1 mapping for subcortical segmentation
    • Magnetisation Transfer: T1-independent MTsat in Multiple Sclerosis and gagCEST in cartilage

→ Previous work performed (click to expand)

  • Functional MRI of several dopaminergic agents, gustatory (taste) stimuli, pain processing, hunger/satiety with endocrine challenge
  • ATP recovery using ischemia, static, and dynamic exercise with 31P MRS in SIRT-1 inhibitors (resveratrol) and COPD
  • Whole body lean and fat imaging for sarcopenia and weight-loss with pharmacological agents
  • Fully tracer-quantified DCE for ovarian metastases, blood brain barrier permeability in Alzheimer's disease, and prostate tumors
  • Sodium concentration imaging in the knee articular cartilage in osteoarthritis
  • Small FOV T2* mapping in the carotids for USPIO uptake as an inflammation marker
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